Knee and Hip OA PRP: Scoping Review
Belk JW · PMC Review (2024)
This scoping review synthesized the PRP evidence for both knee and hip OA, providing a direct comparative framework. For knee OA, PRP was clinically comparable or superior to other injection treatments, with 81% of PRP patients showing significant pre-to-post improvement compared to only 38.1% of HA patients. For hip OA, the evidence was far less consistent, with no significant differences between PRP and HA. The review also found insufficient evidence that leukocyte concentration significantly influences clinical outcomes.
Clinical Relevance
Provides a clear evidence summary for clinicians managing OA across joints. The knee is the strongest indication for PRP in OA, with very favorable response rates. The hip remains uncertain. Clinicians should not assume knee OA results apply to other joints.
Key Takeaways
- Knee OA: 81% of PRP patients showed significant improvement vs 38.1% of HA patients
- Hip OA: inconsistent evidence, no clear PRP advantage over HA
- Leukocyte concentration does not significantly influence outcomes (based on available evidence)
- OA grade matters: better results in earlier stages
- Fundamental difference in PRP response between knee and hip joints
- Further RCTs needed for hip OA, especially with higher concentrations
Key Findings
KNEE OA: favorable - 81% PRP patients improved vs 38.1% HA. HIP OA: INCONSISTENT - no significant PRP vs HA differences. Strong knee evidence, lacking hip evidence.
Clinical Context
Study Design
Scoping Review
Condition
Knee OA and Hip OA (Comparative)
Control Group
HA, CS, Placebo
Primary Outcome
WOMAC, VAS, IKDC, PROs
PRP Protocol & Intervention
Preparation System
Various
Leukocyte Status
Leukocyte effect unclear