PRP in ACLR: Scoping Review of RCTs
Delcogliano M · KSSTA (2024)
DOI: 10.1002/ksa.12127This scoping review mapped all available RCTs on PRP augmentation during ACL reconstruction surgery. The review identified extreme heterogeneity in PRP formulations, application methods (graft soaking, tunnel injection, intra-articular injection, donor site application), outcome measures, and follow-up timepoints. Only 4 of 13 clinical outcome studies showed any PRP benefit, and these were limited to early postoperative timepoints or specific measures like donor site pain.
Clinical Relevance
Current evidence does not support routine PRP augmentation during ACL reconstruction. The scattered positive findings in early postoperative pain suggest PRP may have a role in acute recovery but does not improve long-term reconstruction outcomes. Standardization of protocols is needed before drawing definitive conclusions.
Key Takeaways
- Only 4/13 studies showed any clinical benefit from PRP in ACLR
- Benefits were limited to early timepoints (3 months) or specific measures (donor site pain, VISA score)
- 9/13 studies showed NO advantage of PRP augmentation
- Extreme heterogeneity in PRP application methods across studies
- Evidence is too scattered to support routine PRP use in ACLR
Key Findings
Only 4/13 studies showed benefit. 9/13 no advantage. Evidence scattered.
Clinical Context
Study Design
Scoping Review
Condition
ACLR Augmentation
Follow-up
24 months
Control Group
Standard ACLR
Primary Outcome
Lysholm, IKDC, VAS, MRI
PRP Protocol & Intervention
Preparation System
Various
Leukocyte Status
Mixed
Activation Method
Various
Injection Frequency
1 injection(s)
Guidance Method
Intraoperative