Current Clinical Recommendations for Use of Platelet-Rich Plasma
Le ADK · Current Reviews in Musculoskeletal Medicine (2018)
DOI: 10.1007/s12178-018-9527-7This systematic review by Le and Dragoo assessed the quality and consistency of PRP evidence across multiple orthopedic conditions, producing a graded evidence summary. It remains one of the most cited references for condition-specific PRP recommendations, categorizing evidence as strong, moderate, or lacking for each application.
Clinical Relevance
A foundational reference for evidence-based PRP practice. Clinicians should match PRP formulation to indication: LR-PRP for tendinopathy (especially lateral epicondylitis), LP-PRP for intra-articular applications (especially knee OA). Some conclusions have been updated by newer evidence, particularly for rotator cuff repair.
Key Takeaways
- STRONG evidence for LR-PRP in lateral epicondylitis
- STRONG evidence for LP-PRP in knee osteoarthritis
- MODERATE evidence for patellar tendinopathy and plantar fasciitis
- LACK of efficacy evidence for Achilles tendinopathy, muscle injuries, and rotator cuff repair augmentation (at time of publication)
- Established the framework that different conditions require different PRP formulations
Key Findings
Strong evidence supports LR-PRP for lateral epicondylitis and LP-PRP for knee OA. Moderate evidence for patellar tendinopathy and plantar fasciitis. Lack of efficacy for Achilles tendinopathy, muscle injuries, rotator cuff repair augmentation, and ACL reconstruction.
Clinical Context
Study Design
Systematic Review / Clinical Recommendations
Condition
Multiple Conditions (Systematic Review)
Control Group
Various (comprehensive review)
Primary Outcome
Multiple outcome measures
PRP Protocol & Intervention
Preparation System
Various
Leukocyte Status
LR-PRP and LP-PRP by indication