LP-PRP for Hip OA with DDH: Double-Blind RCT
Okanoue Y · J Hip Preservation Surgery (2025)
DOI: 10.1093/jhps/hnaf008This double-blind RCT tested LP-PRP versus HA specifically in hip OA secondary to developmental dysplasia (DDH), a distinct population from primary OA. The study is notable for its exceptionally detailed PRP characterization using the PAW classification system (P2-x-Bb), 20x platelet concentration, and standardized cryopreservation. Despite this rigorous preparation, PRP showed no significant advantage over HA.
Clinical Relevance
Demonstrates that even well-characterized, high-concentration LP-PRP may not outperform HA in hip OA. The detailed protocol reporting (PAW classification) sets a standard for future studies. The hip joint appears fundamentally less responsive to PRP than the knee.
Key Takeaways
- LP-PRP equivalent to HA for DDH-related hip OA
- Excellent PRP characterization: PAW classification P2-x-Bb, 20x concentration
- Double-spin protocol (200G then 1200G) clearly documented
- Small sample (n=42) limits statistical power
- Even with high-concentration LP-PRP, hip OA shows less PRP response than knee OA
Key Findings
LP-PRP equivalent to HA. No significant difference. Notable for excellent PRP characterization (PAW classification).
Clinical Context
Study Design
RCT (Double-Blind)
Condition
Hip OA from DDH
Sample Size
42 patients
Control Group
Hyaluronic Acid
Primary Outcome
VAS
PRP Protocol & Intervention
Preparation System
FUJISOFT
Leukocyte Status
LP-PRP (PAW: P2-x-Bb)
Platelet Concentration
20x
Spin Protocol
200G 15min then 1200G 15min
Activation Method
None (cryopreserved)
Injection Volume
1 mL
Injection Frequency
3 injection(s)
Injection Interval
Every 4 weeks