Shoulder OA: PRP vs HA with Physical Therapy - Prospective Study
El-Hakeim EH · Journal of Arthritis (2022)
This prospective comparative study evaluated PRP combined with physical therapy versus HA combined with physical therapy for shoulder osteoarthritis. Unlike the rotator cuff studies in the database (which address tendinopathy or surgical repair), this study specifically targets glenohumeral joint osteoarthritis.
Clinical Relevance
For patients with glenohumeral OA who are not candidates for shoulder replacement, PRP represents a potential injection-based option. The evidence is early-stage and limited, but the positive signal aligns with findings in other synovial joints.
Key Takeaways
- PRP + PT superior to HA + PT for shoulder OA
- Addresses glenohumeral joint OA specifically (distinct from rotator cuff disease)
- One of very few studies examining PRP for shoulder joint OA
- Ultrasound guidance used for glenohumeral injection
- Limited evidence level (prospective but non-randomized)
- Shoulder OA is an understudied application for PRP
- Supports the pattern of PRP > HA for synovial joint OA
Key Findings
PRP + physical therapy significantly improved pain and function compared to HA + physical therapy for chronic painful shoulder/glenohumeral OA. One of very few studies examining PRP for glenohumeral (shoulder) joint OA specifically.
Clinical Context
Study Design
Prospective Comparative Study
Condition
Shoulder Osteoarthritis / Chronic Painful Shoulder
Control Group
Hyaluronic Acid + Physical Therapy
Primary Outcome
VAS, ASES, ROM
PRP Protocol & Intervention
Guidance Method
Ultrasound-guided