PRP for Talar Osteochondral Lesions: Systematic Review of Clinical Trials
Defined by multiple authors · BMC Musculoskeletal Disorders (2023)
DOI: 10.1186/s12891-023-06466-yThis systematic review examined PRP for talar cartilage repair, covering both intra-articular injection and surgical augmentation approaches. Ten studies were included, with four RCTs forming the meta-analysis. PRP demonstrated favorable results for both AOFAS function scores and VAS pain scores.
Clinical Relevance
For orthopedic surgeons managing osteochondral lesions of the talus, PRP augmentation after microfracture appears to enhance outcomes. For non-surgical management, intra-articular PRP is a reasonable option.
Key Takeaways
- 10 studies including 4 RCTs for meta-analysis
- PRP favored for AOFAS (MD=7.84) and VAS (MD=1.86)
- Strongest evidence for PRP + microfracture surgery (post-operative augmentation)
- Intra-articular PRP alone also beneficial vs HA
- High heterogeneity (I2=83-85%)
- No PRP-related adverse events reported
- Talar lesions benefit from both surgical and non-surgical PRP approaches
Key Findings
10 studies (4 RCTs, 1 controlled trial, 3 case series, 2 cohort). Meta-analysis of 4 RCTs favored PRP for AOFAS (MD=7.84) and VAS (MD=1.86, p<0.01). PRP as adjunct to microfracture surgery showed strongest evidence.
Clinical Context
Study Design
Systematic Review and Meta-Analysis
Condition
Osteochondral Lesion of the Talus (OLT)
Control Group
HA, Saline, Microfracture alone
Primary Outcome
AOFAS, VAS
PRP Protocol & Intervention
Preparation System
Various
Guidance Method
Intra-articular or post-microfracture