PRP Injection for Thumb CMC OA: Retrospective Case Series
Hasley IB · Arch Rehabil Res Clin Transl (2023)
DOI: 10.1016/j.arrct.2023.100257This retrospective case series from a tertiary care center documented outcomes of ultrasound-guided PRP injections for thumb CMC OA in 19 patients (33 joints). The study is notable for its detailed characterization of both whole blood and PRP cellular composition using the Arthrex Angel system. Most joints were Eaton grade III (54.6%) or IV (24.2%), representing moderate to severe disease.
Clinical Relevance
Provides practical protocol details for clinicians interested in implementing PRP for thumb CMC OA. The Arthrex Angel system specification and injection volumes offer a reproducible protocol. The inclusion of grade IV disease broadens the potential patient population.
Key Takeaways
- 19 patients, 33 thumb CMC joints treated with single PRP injection
- Used Arthrex Angel system with detailed cellular composition reporting
- Erythrocyte and neutrophil-poor PRP preparation
- Mean blood draw 116 mL, mean PRP volume 3.6 mL
- Included severe disease (24.2% grade IV)
- Safe with no major adverse events
- Uncontrolled design limits efficacy conclusions
Key Findings
19 patients, 33 thumb CMC joints. PRP safe and potentially effective. Detailed cellular composition analysis provided. Included all OA grades (II-IV). Single ultrasound-guided injection with erythrocyte/neutrophil-poor PRP.
Clinical Context
Study Design
Retrospective Case Series with Surveys
Condition
Thumb CMC Osteoarthritis (Eaton Grade II-IV)
Sample Size
19 patients
Control Group
None (uncontrolled)
Primary Outcome
VAS, Subjective Improvement, Patient Satisfaction
PRP Protocol & Intervention
Preparation System
Arthrex Angel System
Leukocyte Status
Erythrocyte/Neutrophil-poor PRP
Injection Frequency
1 injection(s)
Guidance Method
Ultrasound-guided