PRP vs HA for Ankle OA: Intra-articular RCT
Repetto I (estimated) · Foot and Ankle Surgery (2017)
This retrospective comparative study examined PRP versus HA for ankle osteoarthritis, contributing to the small but growing evidence base for this application. Both treatments produced improvement from baseline, with mixed results favoring PRP on some measures.
Clinical Relevance
Adds another data point to the ankle OA PRP literature, which remains far less developed than knee OA. Clinicians should recognize that ankle OA PRP evidence is emerging but not yet definitive.
Key Takeaways
- Both PRP and HA improved ankle OA symptoms
- Mixed results across outcome measures
- Retrospective design limits conclusions
- Contributes to small evidence base for ankle OA PRP
- Ankle OA PRP evidence far behind knee OA
- Need for prospective RCTs in ankle OA specifically
- Xiong 2023 meta-analysis provides supportive pooled evidence
Key Findings
Retrospective comparison of PRP vs HA for ankle OA. Both treatments showed improvement. Mixed results with some measures favoring PRP and others showing equivalence. Limited by retrospective design.
Clinical Context
Study Design
Retrospective Comparative Study
Condition
Ankle Osteoarthritis
Control Group
Hyaluronic Acid
Primary Outcome
VAS, AOFAS, FAAM