PRP vs HA for Talar OLT: RCT with Superior PRP Outcomes at 28 Weeks
Mei-Dan O · Foot & Ankle International (2012)
DOI: 10.3113/FAI.2012.0806This RCT compared three weekly intra-articular PRP injections versus three weekly HA injections in 30 patients with talar dome osteochondral lesions who had failed conservative management. At 28 weeks, the PRP group demonstrated significantly less pain and better function across multiple outcome measures.
Clinical Relevance
For patients with symptomatic talar osteochondral lesions who are not surgical candidates or prefer conservative management, PRP is superior to HA. The 3-weekly injection protocol is practical and well-tolerated.
Key Takeaways
- First RCT for PRP vs HA in talar osteochondral lesions
- PRP significantly superior for pain and function at 28 weeks
- 3 weekly injections in both groups
- All patients had failed conservative management
- 30 patients (small but randomized)
- AHFS, AOFAS, and VAS all favored PRP
- Establishes PRP as preferred injection for talar OLT
Key Findings
30 patients with talar dome lesions refractory to conservative care. PRP had significantly less pain and improved function vs HA at 28 weeks. First RCT demonstrating PRP superiority over HA for talar osteochondral lesions.
Clinical Context
Study Design
Randomized Controlled Trial
Condition
Talar Dome Osteochondral Lesion (Conservative Treatment Failure)
Sample Size
30 patients
Follow-up
7 months
Control Group
Hyaluronic Acid (3 weekly injections)
Primary Outcome
AHFS, AOFAS, VAS
PRP Protocol & Intervention
Injection Frequency
3 injection(s)
Injection Interval
Weekly
Guidance Method
Intra-articular