Plasma Rich in Growth Factors Versus Corticosteroid Injections for Management of Chronic Rotator Cuff Tendinopathy
Sánchez M · Journal of Shoulder and Elbow Surgery (2022)
This double-blind RCT using the PRGF (Plasma Rich in Growth Factors) system tested LP-PRP versus HA in 100 patients with chronic supraspinatus tendinopathy. Unlike Kesikburun 2013, this study found PRP significantly superior to HA, with ASES scores of 89.8 versus 78.0 at final follow-up. The use of PRGF (a specific LP-PRP preparation with standardized growth factor content) and larger sample size may explain the different outcome.
Clinical Relevance
Demonstrates that PRP preparation method critically influences outcomes in rotator cuff tendinopathy. The PRGF system (LP-PRP with standardized growth factors) may be superior to generic PRP preparations for this indication.
Key Takeaways
- PRP (PRGF) significantly superior to HA (ASES 89.8 vs 78.0, p<0.001)
- Used LP-PRP specifically (PRGF system)
- Larger sample (n=100) than Kesikburun study
- Contradicts Kesikburun 2013 negative result, suggesting preparation method matters
- PRGF system provides standardized growth factor content
Key Findings
PRP showed significantly superior pain relief and functional improvement vs corticosteroid at 12 months (ASES 89.8 vs 78.0, p<0.001). Failure rate was higher in corticosteroid group (30% vs 12%).
Clinical Context
Study Design
Randomized Controlled Trial (Double-Blind)
Condition
Chronic Rotator Cuff Tendinopathy (Supraspinatus)
Sample Size
100 patients
Follow-up
12 months
Control Group
Corticosteroid
Primary Outcome
VAS, ASES, SANE, PSQI
PRP Protocol & Intervention
Preparation System
PRGF (Plasma Rich in Growth Factors)
Leukocyte Status
LP-PRP
Injection Frequency
1 injection(s)