Arthroscopy-Guided PRP for Grade II Meniscus Tears: RCT
Teimouri M · Int J Burns Trauma (2025)
This RCT evaluated arthroscopy-guided PRP injection for grade II meniscus tears in 90 patients who were also undergoing ACL reconstruction. At 6 months, there was a trend toward improved MRI healing in the PRP group (p=0.0552) that did not reach statistical significance. By 12 months, no differences were detected. Clinical scores showed slight, non-significant improvements in the PRP group. The study concludes that PRP is not a standalone treatment for grade II meniscus tears.
Clinical Relevance
PRP injection does not appear to meaningfully improve grade II meniscus tear healing when added to conservative management during ACL reconstruction. The near-significant 6-month trend suggests there may be a modest biological effect, but it does not translate to clinically detectable benefit.
Key Takeaways
- Trend toward improved healing at 6 months (p=0.0552) but not significant
- No difference at 12 months
- Clinical scores not significantly improved
- 90 patients (adequate sample size)
- Arthroscopy-guided injection (precise delivery)
- PRP not effective as standalone meniscus treatment
Key Findings
Trend at 6mo (p=0.0552) but NOT significant at 6 or 12 months. PRP NOT superior for grade II meniscus.
Clinical Context
Study Design
RCT
Condition
Grade II Meniscus Tears with ACLR
Sample Size
90 patients
Follow-up
12 months
Control Group
Conservative treatment
Primary Outcome
MRI healing, clinical scores
PRP Protocol & Intervention
Injection Frequency
1 injection(s)
Guidance Method
Arthroscopy-guided