PRP for OA by Joint Type: Meta-Analysis (Ankle, Knee, Hip, TMJ)
Xiong Y · Frontiers in Medicine (2023)
DOI: 10.3389/fmed.2023.1204144This comprehensive meta-analysis of 24 RCTs with 1344 OA patients uniquely analyzed PRP efficacy by joint location, providing the first systematic joint-by-joint comparison. Ankle OA, knee OA, and TMJ OA all showed significant VAS improvement with PRP. However, hip OA showed no significant benefit. A subanalysis found LP-PRP produced greater analgesic effects than LR-PRP across all joints.
Clinical Relevance
Establishes that PRP efficacy is joint-specific. Clinicians can confidently recommend PRP for ankle and knee OA but should not assume efficacy for hip OA. The LP-PRP advantage across joints reinforces the recommendation for leukocyte-poor formulations in intra-articular applications.
Key Takeaways
- Ankle OA: significant PRP benefit (MD=-1.15, p<0.05)
- Knee OA: significant PRP benefit (MD=-1.03, p<0.05)
- TMJ OA: significant PRP benefit (MD=-1.35, p<0.05)
- Hip OA: NO significant benefit (MD=-0.27, p>0.05)
- LP-PRP more effective than LR-PRP across all joints
- 24 RCTs, 1344 patients covering 4 joint types
Key Findings
Ankle OA (MD=-1.15, p<0.05), Knee OA (MD=-1.03, p<0.05), TMJ OA (MD=-1.35, p<0.05) all significant. Hip OA NO benefit (MD=-0.27, p>0.05). LP-PRP > LR-PRP. PRP works differently across joints.
Clinical Context
Study Design
Systematic Review and Meta-Analysis
Condition
Osteoarthritis (all joints - 24 RCTs)
Sample Size
1344 patients
Control Group
HA, Saline, Corticosteroids
Primary Outcome
VAS Pain Score
PRP Protocol & Intervention
Preparation System
Various
Leukocyte Status
LP-PRP showed greater analgesic effect than LR-PRP